Intermittent fasting can also reduce high blood pressure! “Circulation”: Restructuring the intestinal flora in stomach

Intestinal bacteria in the stomach can also change the level of blood pressure? In the past, it has been known that intestinal bacteria are closely related to many diseases. The latest research from Baylor College of Medicine found that changes in diet can achieve recombination of intestinal bacteria and lower blood pressure, especially the effect of ” intermittent fasting “.

Poor intestinal flora negatively affects blood pressure

Hypertension has always been a common problem among Chinese people. In addition to being improved by drugs, exercise, etc., “intermittent fasting” may also be one of the methods that can help improve in the future. The research results are also published in the international journal “Circulation” ( Circulation). Research) magazine.


Beile Daxue Anesthesiology Assistant Professor David · Toure Gan ( David Durgan ) pointed out that in previous studies, the mice do have high blood pressure compared with the general normotensive rats, both the intestinal microflora is different and There is increasing evidence that poor intestinal flora can have a negative impact on blood pressure.

In order to prove this, the researchers transplanted the bad intestinal flora of hypertensive mice into healthy mice, and healthy mice did produce high bp . Durgan said: “The results tell us that the intestinal flora is not only the result of high blood pressure, it is also very likely the cause of high blood pressure.”

Intermittent fasting can change the composition of intestinal bacteria

Therefore, researchers want to use intestinal bacteria to prevent and alleviate the problem of high blood pressure, and conduct a series of experiments on this hypothesis. They found rats with spontaneous hypertension and normal rats and divided them into two groups. One group was fed with hypertensive and normal rats every day, and the food supply was not restricted. The other group was the control group, and the rats were fed only once every two days.

After nine weeks of comparison, the researchers found that the blood pressure of the rats that were not controlled by the diet was higher, and the blood pressure of the rats in the intermittent fasting group was significantly lower. “These results show that fasting can change the microbiota sufficiently to affect the bp lowering effect of intermittent fasting.” Durgan pointed out.

How do intestinal bacteria in the intestine lower blood pressure?

These findings led the researchers to ask the next question: How do microorganisms in the intestine lower bp? The answer seems to be attributed to the amount of beneficial acids in the patient’s intestines. Durgan said: “We have applied the whole genome sequence analysis of the microbiota, and the observed changes, bile acids may be a potential key to bp regulation.”

Bile acids are not the first bile produced by hepatocytes , but the products formed after the degradation of intestinal bacteria and the intestinal hepatic circulation . The study found that hypertensive rats on a normal diet had less bile acids than rats with normal blood pressure; on the contrary, rats in the intermittent fasting group had more bile acids.

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In recent years, more and more people have become popular with intermittent fasting, changing their dietary habits to help regulate the intestinal microbial population, thereby naturally providing health benefits. And there are many studies on similar inferences that intermittent fasting can improve a variety of chronic diseases, including obesity, diabetes , cardiovascular disease, and neurodegenerative diseases of the brain.

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